Ku protein - Ku protein - qaz.wiki

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Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Required for mating-type switching (By similarity). KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase.

Required also for telomere recombination to repair telomeric ends in the absence of telomerase.

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14375 Ensembl ENSG00000196419 ENSMUSG00000022471 UniProt P12956 P23475 RefSeq (mRNA) NM_001469 NM_001288976 NM_001288977 NM_001288978 NM_010247 RefSeq (protein) NP_001275905 NP_001275906 NP_001275907 NP_001460 NP_001275905.1 NP_001460.1 NP_034377 Location (UCSC) Chr 22: 41.62 – 41.66 Mb Chr 15: 81.99 – 82.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ku70 is a protein that 2007-01-23 · Heterodimer composed of XRCC5/Ku80 and XRCC6/Ku70. The dimer associates in a DNA-dependent manner with PRKDC to form the DNA-dependent protein kinase complex DNA-PK, and with the LIG4-XRCC4 complex to form the core of the non-homologous end joining (NHEJ) complex (PubMed:25941166, PubMed:25670504, PubMed:11493912, PubMed:22442688). 2008-02-05 · Heterodimer composed of XRCC5/Ku80 and XRCC6/Ku70.

P38 mapk-signalering och fosforyleringar i brct1-domänen

Knockdown of Ku70 was achieved by transfecting HeLa with Ku70 specific siRNAs (Silencer® select Product # S5455, S5457). Western blot analysis (Fig. a) was performed using Nuclear enriched extracts from the Ku70 knockdown cells (lane 3), non-targeting scrambled siRNA transfected cells (lane 2) and untransfected cells (lane 1). Knockdown of Ku70 was achieved by transfecting HeLa cells with Ku70 specific siRNAs (Silencer® select Product # s5457, s5455). Western blot analysis (Fig.

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The Ku70/Ku80 complex functions as a single-stranded DNA-dependent ATP-dependent helicase. XRCC6 / Ku70 Protein LS-G28542 is a Recombinant Human XRCC6 / Ku70 produced in Wheat Germ Extract with GST tag(s).

Lane 6: A431 Whole Cell Lysate at 40ug. Ku70 is the 70 kDa subunit of the lupus Ku autoantigen. The lupus Ku autoantigen was identified in individuals with systemic lupus erythematosus (SLE) and related disorders. The Ku antigen is a heterodimer of Ku70 and Ku80.
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P38 mapk-signalering och fosforyleringar i brct1-domänen

Invitrogen Anti-Ku70 Polyclonal, Catalog # PA5-27538.

P38 mapk-signalering och fosforyleringar i brct1-domänen

The assembly of the DNA-PK complex at DNA ends is required for nonhomologous end-joining (NHEJ), one mechanism involved in double-stranded DNA break repair and V(D)J recombination (8). Two of these proteins, Ku70 and Ku80, were identified by immunoblot analysis. The third polypeptide, which was identified by mass spectrometry analysis, is identical to poly(ADP-ribose) polymerase-1(PARP-1), a 113-kDa enzyme that functions as a sensor of DNA damage. 55K isoform of CDK9 associates with Ku70 and is involved in DNA repair. Liu H., Herrmann C.H., Chiang K., Sung T.L., Moon S.H., Donehower L.A., Rice A.P. Positive elongation factor b (P-TEFb) is a cellular protein kinase that is required for RNA polymerase II (RNAP II) … Invitrogen Anti-Ku70 Recombinant Monoclonal (JM61-31), Catalog # MA5-32645.

The third polypeptide, which was identified by mass spectrometry analysis, is identical to poly(ADP-ribose) polymerase-1(PARP-1), a 113-kDa enzyme that functions as a sensor of DNA damage. 55K isoform of CDK9 associates with Ku70 and is involved in DNA repair.